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Antimicrobial Agents and Chemotherapy, March 2006, p. 1100-1103, Vol. 50, No. 3
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.3.1100-1103.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Roles of Cellular Respiration, CgCDR1, and CgCDR2 in Candida glabrata Resistance to Histatin 5

Eva J. Helmerhorst,1* Caterina Venuleo,1 Dominique Sanglard,2 and Frank G. Oppenheim1

Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, 700 Albany Street, Boston, Massachusetts 02118,1 Institute of Microbiology, University Hospital Lausanne (CHUV), Rue de Bugnon 48, CH-1011 Lausanne, Switzerland2

Received 13 September 2005/ Returned for modification 10 October 2005/ Accepted 4 January 2006

Histatin 5, a human salivary protein with broad-spectrum antifungal activity, is remarkably ineffective against Candida glabrata. Fluconazole resistance in this fungus is due in most cases to upregulation of CgCDR efflux pumps. We investigated whether the distinct resistance of C. glabrata to histatin 5 is related to similar mechanisms.

* Corresponding author. Mailing address: Boston University, Goldman School of Dental Medicine, Department of Periodontology and Oral Biology, 700 Albany St., CABR W-201, Boston, MA 02118. Phone: (617) 414-1119. Fax: (617) 638-4924. E-mail: helmer{at}bu.edu.

Antimicrobial Agents and Chemotherapy, March 2006, p. 1100-1103, Vol. 50, No. 3
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.3.1100-1103.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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