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Antimicrobial Agents and Chemotherapy, March 2006, p. 1104-1107, Vol. 50, No. 3
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.3.1104-1107.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

NorC, a New Efflux Pump Regulated by MgrA of Staphylococcus aureus

Division of Infectious Diseases and Medical Services, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114-2696

Received 24 October 2005/ Returned for modification 28 November 2005/ Accepted 4 January 2006

NorC, a new efflux pump, like NorB, contributes to quinolone resistance that includes resistance to moxifloxacin and sparfloxacin in Staphylococcus aureus. norC expression, like that of norB and tet38, is negatively regulated by MgrA, and overexpression of both norC and norB contributes to the quinolone resistance phenotype of an mgrA mutant.

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