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Antimicrobial Agents and Chemotherapy, March 2006, p. 1108-1111, Vol. 50, No. 3
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.3.1108-1111.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Evaluation of Disk Diffusion Method for Determining Posaconazole Susceptibility of Filamentous Fungi: Comparison with CLSI Broth Microdilution Method

E. López-Oviedo,1 A. I. Aller,1 C. Martín,1 C. Castro,1 M. Ramirez,1 J. M. Pemán,2 E. Cantón,2 C. Almeida,3 and E. Martín-Mazuelos1*

S. Microbiología,1 S. Bioestadística, U. Investigación, Valme University Hospital, Seville, Spain,3 La Fe University Hospital, Valencia, Spain2

Received 8 November 2005/ Returned for modification 21 November 2005/ Accepted 3 January 2006

The disk diffusion method was evaluated for determining posaconazole susceptibility against 78 strains of molds using two culture media in comparison with the CLSI (Clinical Laboratory Standards Institute) broth microdilution method (M38-A). A significant correlation between disk diffusion and microdilution methods was observed with both culture media.

* Corresponding author. Mailing address: Hospital Universitario de Valme, Servicio Microbiología, Ctra de Ca diz s/n, Seville, Spain. Phone: 34-955015480. Fax: 34-955015481. E-mail: estrella.martin.sspa{at}juntadeandalucia.es.

Antimicrobial Agents and Chemotherapy, March 2006, p. 1108-1111, Vol. 50, No. 3
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.3.1108-1111.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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