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Antimicrobial Agents and Chemotherapy, March 2006, p. 1112-1117, Vol. 50, No. 3
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.3.1112-1117.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Activities of Tizoxanide and Nitazoxanide Compared to Those of Five Other Thiazolides and Three Other Agents against Anaerobic Species

Glenn A. Pankuch and Peter C. Appelbaum*

Departments of Pathology, Hershey Medical Center, Hershey, Pennsylvania

Received 27 October 2005/ Returned for modification 29 November 2005/ Accepted 3 January 2006

Agar dilution was used, and MICs of metronidazole, tizoxanide, nitazoxanide, denitrotizoxanide, RM 4803, RM 4807, RM 4809, RM 4819, amoxicillin-clavulanate, and clindamycin were measured against 412 anaerobes. Nitazoxanide, tizoxanide, RM 4807, and RM 4809 were active against all groups, except for gram-positive non-spore-forming rods with 50% minimum inhibitory concentrations (when the latter were excluded) of 1 to 2 µg/ml and 90% minimum inhibitory concentrations of 4 to 8 µg/ml, respectively. Metronidazole MICs were usually lower against all groups except clostridia.

* Corresponding author. Mailing address: Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033. Phone: (717) 531-5113. Fax: (717) 531-7953. E-mail: pappelbaum{at}psu.edu.

Antimicrobial Agents and Chemotherapy, March 2006, p. 1112-1117, Vol. 50, No. 3
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.3.1112-1117.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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