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Antimicrobial Agents and Chemotherapy, April 2006, p. 1535-1537, Vol. 50, No. 4
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.4.1535-1537.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Antimalarial Activity of a Synthetic Endoperoxide (RBx-11160/OZ277) against Plasmodium falciparum Isolates from Gabon

Andrea Kreidenweiss,1,2,{dagger} Benjamin Mordmüller,1,2,{dagger}* Sanjeev Krishna,1,3 and Peter G. Kremsner1,2

Medical Research Laboratory, Albert Schweitzer Hospital, Lambaréné, Gabon,1 Department of Parasitology, University of Tübingen, Germany,2 Division of Cellular and Molecular Medicine, Centre for Infection, St. George's, University of London, Cranmer Terrace, London, SW17 0RE, Great Britain3

Received 11 November 2005/ Returned for modification 28 January 2006/ Accepted 9 February 2006

OZ277 is a newly developed, fully synthetic endoperoxide antimalarial that we tested against field isolates from Gabon. A comparison of activities of OZ277 with artesunate, mefloquine, and chloroquine showed OZ277 to be highly active against all parasite isolates. Artesunate and mefloquine also showed potent antiparasitic activity, but all isolates were chloroquine resistant.

* Corresponding author. Mailing address: Department of Parasitology, University of Tübingen, Wilhelmstr. 27, D-72074 Tübingen, Germany. Phone: 49 7071 2980240. Fax: 49 7071 295189. E-mail: benjamin.mordmueller{at}uni-tuebingen.de.

{dagger} These two authors contributed equally to this work.

Antimicrobial Agents and Chemotherapy, April 2006, p. 1535-1537, Vol. 50, No. 4
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.4.1535-1537.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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