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Antimicrobial Agents and Chemotherapy, April 2006, p. 1538-1540, Vol. 50, No. 4
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.4.1538-1540.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Gatifloxacin Resistance and Mutations in gyrA after Unsuccessful Helicobacter pylori Eradication in Japan

Toshihiro Nishizawa,1 Hidekazu Suzuki,1,4* Kumiko Kurabayashi,2 Tatsuhiro Masaoka,3 Hiroe Muraoka,5 Mikiji Mori,1 Eisuke Iwasaki,1 Intetsu Kobayashi,5 and Toshifumi Hibi1

Department of Internal Medicine,1 Center for Integrated Medical Research,2 Department of Emergency Medicine,3 Keio University School of Medicine, Department of Gastroenterology, Kitasato Institute Hospital,4 Mitsubishi Kagaku Bio-Clinical Laboratories, Tokyo, Japan5

Received 17 September 2005/ Returned for modification 12 December 2005/ Accepted 30 January 2006

A high resistance rate (47.9%) to gatifloxacin (GAT; 8-methoxy fluoroquinolone) in Helicobacter pylori (H. pylori) strains from 48 Japanese patients is observed after unsuccessful H. pylori eradication. A significant association between MICs for GAT equal to or above 1 µg/ml and mutations of the gyrA gene of H. pylori was demonstrated.

* Corresponding author. Mailing address: Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. Phone: 81-3-5363-3914. Fax: 81-3-5363-3967. E-mail: hsuzuki{at}sc.itc.keio.ac.jp.

Antimicrobial Agents and Chemotherapy, April 2006, p. 1538-1540, Vol. 50, No. 4
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.4.1538-1540.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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