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Antimicrobial Agents and Chemotherapy, April 2006, p. 1541-1545, Vol. 50, No. 4
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.4.1541-1545.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Autolytic Properties of Glycopeptide-Intermediate Staphylococcus aureus Mu50

Sugunya Utaida, Richard F. Pfeltz, R. K. Jayaswal, and B. J. Wilkinson^*

Microbiology Group, Department of Biological Sciences, Illinois State University, Normal, Illinois 61790-4120

Received 14 September 2005/ Returned for modification 15 November 2005/ Accepted 26 January 2006

Whole-cell autolytic activity of prototypical glycopeptide-intermediate Staphylococcus aureus (GISA) Mu50 was reduced versus that of hetero-GISA Mu3 and glycopeptide-susceptible S. aureus, consistent with other GISA strains. In contrast, autolytic activity was relatively high in Mu50 crude cell walls and autolysin extracts against purified cell walls, reflecting the complexities of autolytic activity regulation.

Present address: Department of Biotechnology, Faculty of Science and Technology, Thammasat University, Rangsit Center, Prathum Tani, 12121, Thailand.

Present address: BD Diagnostic Systems, Sparks, MD 21152.

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