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Antimicrobial Agents and Chemotherapy, April 2006, p. 1558-1560, Vol. 50, No. 4
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.4.1558-1560.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Bactericidal Activities of R207910 and Other Newer Antimicrobial Agents against Mycobacterium leprae in Mice

Baohong Ji,1* Aurélie Chauffour,1 Koen Andries,2 and Vincent Jarlier1

Bactériologie-Hygiène, Faculté de Médecine Pierre et Marie Curie, Université Paris 6, Paris, France,1 Johnson & Johnson Pharmaceutical Research and Development, Beerse, Belgium2

Received 8 November 2005/ Returned for modification 10 December 2005/ Accepted 1 February 2006

As measured by a proportional bactericidal technique in the mouse footpad system, the bactericidal activity against Mycobacterium leprae of R207910 was equal to that of rifapentine, rifampin, or moxifloxacin and significantly greater than those of minocycline, PA-824, and linezolid. These data suggest that R207910 may play an important role in treatment of leprosy.

* Corresponding author. Mailing address: Bactériologie-Hygiène, Faculté de Médecine Pierre et Marie Curie, Université Paris 6, 91 Boulevard de l'Hôpital, 75634 Paris Cedex 13, France. Phone: (331) 40 77 98 67. Fax: (331) 45 82 75 77. E-mail: baohong_ji{at}yahoo.com.

Antimicrobial Agents and Chemotherapy, April 2006, p. 1558-1560, Vol. 50, No. 4
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.4.1558-1560.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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  • Duthie, M. S., Reece, S. T., Lahiri, R., Goto, W., Raman, V. S., Kaplan, J., Ireton, G. C., Bertholet, S., Gillis, T. P., Krahenbuhl, J. L., Reed, S. G. (2007). Antigen-Specific Cellular and Humoral Responses Are Induced by Intradermal Mycobacterium leprae Infection of the Mouse Ear. Infect. Immun. 75: 5290-5297 [Abstract] [Full Text]  
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