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Antimicrobial Agents and Chemotherapy, April 2006, p. 1561-1563, Vol. 50, No. 4
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.4.1561-1563.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Prevalence of First-Step Mutants among Levofloxacin-Susceptible Invasive Isolates of Streptococcus pneumoniae in the United States

Mathias W. R. Pletz,^1,2,3* Ardaman P. Shergill,¹ Lesley McGee,^1,3 Bernard Beall,³ Cynthia G. Whitney,³ Keith P. Klugman,^1,3 for the Active Bacterial Core Surveillance Team,³

Hubert Department of Global Health, Rollins School of Public Health, and Division of Infectious Diseases, School of Medicine, Emory University, Atlanta, Georgia,¹ Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany,² Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia³

Received 19 July 2005/ Returned for modification 31 October 2005/ Accepted 25 January 2006

By use of a PCR-restriction fragment length polymorphism assay, we screened 496 levofloxacin-susceptible invasive pneumococcal strains (MIC 2 mg/liter) for quinolone resistance-determining region mutations known to confer fluoroquinolone resistance. Among those with a levofloxacin MIC of 2 mg/liter, 16.2% of isolates recovered from nursing home residents and 6.4% from non-nursing home residents had first-step mutations.

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* Corresponding author. Mailing address: Department of Respiratory Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, Hannover 30625, Germany. Phone: 49 (511) 532-9612. Fax: 49 (511) 532-8419. E-mail: Pletz.Mathias{at}mh-hannover.de.

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Antimicrobial Agents and Chemotherapy, April 2006, p. 1561-1563, Vol. 50, No. 4
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.4.1561-1563.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

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