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Antimicrobial Agents and Chemotherapy, April 2006, p. 1564-1566, Vol. 50, No. 4
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.4.1564-1566.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Ether Lipid Ester Derivatives of Cidofovir Inhibit Polyomavirus BK Replication In Vitro

Parmjeet Randhawa,1* Noush Afarin Farasati,1 Ron Shapiro,2 and Karl Y. Hostetler3

Departments of Pathology,1 Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania,2 Department of Medicine, University of California at San Diego, La Jolla, California3

Received 4 July 2005/ Returned for modification 31 October 2005/ Accepted 30 January 2006

Polyomavirus BK is a significant pathogen in transplant recipients, but no effective antiviral therapy is available. We show that cidofovir can inhibit BK virus replication in vitro. Esterification of cidofovir with hexadecyloxypropyl, octadecyloxyethyl, and oleyloxyethyl groups results in up to a 3-log lowering of the 50% effective concentration and an increased selectivity index.

* Corresponding author. Mailing address: Division of Transplantation Pathology, Department of Pathology, University of Pittsburgh, Room E737, UPMC-Montefiore Hospital, 3459 Fifth Ave., Pittsburgh, PA 15213. Phone: (412) 647-7646. Fax: (412) 647-5237. E-mail: randhawapa{at}msx.upmc.edu.

Antimicrobial Agents and Chemotherapy, April 2006, p. 1564-1566, Vol. 50, No. 4
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.4.1564-1566.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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