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Immunotherapy with Tacrolimus (FK506) Does Not Select for Resistance to Calcineurin Inhibitors in Candida albicans Isolates from Liver Transplant Patients

Departments of Molecular Genetics and Microbiology,¹ Medicine, Duke University Medical Center, Durham, North Carolina,⁵ Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania,² Division of Infectious Diseases and International Health,³ Department of Surgery, University of Virginia Health System, Charlottesville, Virginia⁴

Received 30 September 2005/ Returned for modification 23 November 2005/ Accepted 11 January 2006

In Candida albicans, calcineurin mediates tolerance to azole antifungal drugs, survival in serum, and virulence. In this study, we examined 24 Candida isolates from liver transplant recipients receiving a calcineurin inhibitor as a component of their immunosuppressive therapy. We were unable to detect a difference in susceptibility to calcineurin inhibitors in combination with fluconazole, serum, or calcium in these isolates.

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• Uppuluri, P., Nett, J., Heitman, J., Andes, D. (2008). Synergistic Effect of Calcineurin Inhibitors and Fluconazole against Candida albicans Biofilms. Antimicrob. Agents Chemother. 52: 1127-1132 [Abstract] [Full Text]