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Antimicrobial Agents and Chemotherapy, April 2006, p. 1581-1585, Vol. 50, No. 4
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.4.1581-1585.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Induction of Daptomycin Heterogeneous Susceptibility in Staphylococcus aureus by Exposure to Vancomycin

George Sakoulas,1* Jeff Alder,2 Claudie Thauvin-Eliopoulos,3 Robert C. Moellering Jr.,3 and George M. Eliopoulos3

Division of Infectious Diseases, New York Medical College, and Westchester Medical Center, Valhalla, New York 10595,1 Cubist Pharmaceuticals, Lexington, Massachusetts,2 Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts3

Received 9 September 2005/ Returned for modification 27 December 2005/ Accepted 12 January 2006

We studied vancomycin and daptomycin susceptibility in methicillin-resistant Staphylococcus aureus from patients exposed to vancomycin, glycopeptide-intermediate S. aureus, and S. aureus passaged in vancomycin-containing medium. A correlation between vancomycin and daptomycin heteroresistance was noted in some strains, suggesting that exposure of S. aureus to vancomycin may affect susceptibility to daptomycin.

* Corresponding author. Mailing address: Department of Medicine, Division of Infectious Diseases, New York Medical College, Munger Pavilion, Room 245, Valhalla, NY 10595. Phone: (914) 594-4974. Fax: (845) 361-1156. E-mail: george_sakoulas{at}nymc.edu.

Antimicrobial Agents and Chemotherapy, April 2006, p. 1581-1585, Vol. 50, No. 4
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.4.1581-1585.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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