This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sakoulas, G. Articles by Eliopoulos, G. M. Search for Related Content PubMed PubMed Citation Articles by Sakoulas, G. Articles by Eliopoulos, G. M.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, April 2006, p. 1581-1585, Vol. 50, No. 4
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.4.1581-1585.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Induction of Daptomycin Heterogeneous Susceptibility in Staphylococcus aureus by Exposure to Vancomycin

Division of Infectious Diseases, New York Medical College, and Westchester Medical Center, Valhalla, New York 10595,¹ Cubist Pharmaceuticals, Lexington, Massachusetts,² Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts³

Received 9 September 2005/ Returned for modification 27 December 2005/ Accepted 12 January 2006

We studied vancomycin and daptomycin susceptibility in methicillin-resistant Staphylococcus aureus from patients exposed to vancomycin, glycopeptide-intermediate S. aureus, and S. aureus passaged in vancomycin-containing medium. A correlation between vancomycin and daptomycin heteroresistance was noted in some strains, suggesting that exposure of S. aureus to vancomycin may affect susceptibility to daptomycin.

This article has been cited by other articles:

• Murthy, M. H., Olson, M. E., Wickert, R. W., Fey, P. D., Jalali, Z. (2008). Daptomycin non-susceptible meticillin-resistant Staphylococcus aureus USA 300 isolate. J Med Microbiol 57: 1036-1038 [Abstract] [Full Text]  
• Rose, W. E., Leonard, S. N., Sakoulas, G., Kaatz, G. W., Zervos, M. J., Sheth, A., Carpenter, C. F., Rybak, M. J. (2008). Daptomycin Activity against Staphylococcus aureus following Vancomycin Exposure in an In Vitro Pharmacodynamic Model with Simulated Endocardial Vegetations. Antimicrob. Agents Chemother. 52: 831-836 [Abstract] [Full Text]  
• Muthaiyan, A., Silverman, J. A., Jayaswal, R. K., Wilkinson, B. J. (2008). Transcriptional Profiling Reveals that Daptomycin Induces the Staphylococcus aureus Cell Wall Stress Stimulon and Genes Responsive to Membrane Depolarization. Antimicrob. Agents Chemother. 52: 980-990 [Abstract] [Full Text]  
• Montero, C. I., Stock, F., Murray, P. R. (2008). Mechanisms of Resistance to Daptomycin in Enterococcus faecium. Antimicrob. Agents Chemother. 52: 1167-1170 [Abstract] [Full Text]  
• Huang, Y.-T., Hsiao, C.-H., Liao, C.-H., Lee, C.-W., Hsueh, P.-R. (2008). Bacteremia and Infective Endocarditis Caused by a Non-Daptomycin-Susceptible, Vancomycin-Intermediate, and Methicillin-Resistant Staphylococcus aureus Strain in Taiwan. J. Clin. Microbiol. 46: 1132-1136 [Abstract] [Full Text]  
• Moise, P. A., Smyth, D. S., El-Fawal, N., Robinson, D. A., Holden, P. N., Forrest, A., Sakoulas, G. (2008). Microbiological effects of prior vancomycin use in patients with methicillin-resistant Staphylococcus aureus bacteraemia. J Antimicrob Chemother 61: 85-90 [Abstract] [Full Text]  
• Jones, T., Yeaman, M. R., Sakoulas, G., Yang, S.-J., Proctor, R. A., Sahl, H.-G., Schrenzel, J., Xiong, Y. Q., Bayer, A. S. (2008). Failures in Clinical Treatment of Staphylococcus aureus Infection with Daptomycin Are Associated with Alterations in Surface Charge, Membrane Phospholipid Asymmetry, and Drug Binding. Antimicrob. Agents Chemother. 52: 269-278 [Abstract] [Full Text]  
• Sakoulas, G., Rose, W., Rybak, M. J., Pillai, S., Alder, J., Moellering, R. C. Jr., Eliopoulos, G. M. (2008). Evaluation of Endocarditis Caused by Methicillin-Susceptible Staphylococcus aureus Developing Nonsusceptibility to Daptomycin. J. Clin. Microbiol. 46: 220-224 [Abstract] [Full Text]  
• Pillai, S. K., Gold, H. S., Sakoulas, G., Wennersten, C., Moellering, R. C. Jr., Eliopoulos, G. M. (2007). Daptomycin Nonsusceptibility in Staphylococcus aureus with Reduced Vancomycin Susceptibility Is Independent of Alterations in MprF. Antimicrob. Agents Chemother. 51: 2223-2225 [Abstract] [Full Text]  
• Tsuji, B. T., Rybak, M. J., Lau, K. L., Sakoulas, G. (2007). Evaluation of Accessory Gene Regulator (agr) Group and Function in the Proclivity towards Vancomycin Intermediate Resistance in Staphylococcus aureus. Antimicrob. Agents Chemother. 51: 1089-1091 [Abstract] [Full Text]  
• Goldstein, F. (2007). The potential clinical impact of low-level antibiotic resistance in Staphylococcus aureus. J Antimicrob Chemother 59: 1-4 [Abstract] [Full Text]  
• French, G. L. (2006). Bactericidal agents in the treatment of MRSA infections--the potential role of daptomycin. J Antimicrob Chemother 58: 1107-1117 [Abstract] [Full Text]  
• Wootton, M., MacGowan, A. P., Walsh, T. R. (2006). Comparative Bactericidal Activities of Daptomycin and Vancomycin against Glycopeptide-Intermediate Staphylococcus aureus (GISA) and Heterogeneous GISA Isolates. Antimicrob. Agents Chemother. 50: 4195-4197 [Abstract] [Full Text]  
• Jevitt, L. A., Thorne, G. M., Traczewski, M. M., Jones, R. N., McGowan, J. E. Jr., Tenover, F. C., Brown, S. D. (2006). Multicenter Evaluation of the Etest and Disk Diffusion Methods for Differentiating Daptomycin-Susceptible from Non-Daptomycin-Susceptible Staphylococcus aureus Isolates.. J. Clin. Microbiol. 44: 3098-3104 [Abstract] [Full Text]  
• Mariani, P. G., Sader, H. S., Jones, R. N. (2006). Development of decreased susceptibility to daptomycin and vancomycin in a Staphylococcus aureus strain during prolonged therapy. J Antimicrob Chemother 58: 481-483 [Full Text]