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Antimicrobial Agents and Chemotherapy, April 2006, p. 1603-1607, Vol. 50, No. 4
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.4.1603-1607.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Large Conjugative Plasmids from Clinical Strains of Salmonella enterica Serovar Virchow Contain a Class 2 Integron in Addition to Class 1 Integrons and Several Non-Integron-Associated Drug Resistance Determinants

Departamento de Biología Funcional-Microbiología, Universidad de Oviedo and Instituto Universitario de Biotecnología de Asturias (IUBA), 33006-Oviedo, Spain,¹ Instituto de Productos Lácteos de Asturias (CSIC), 33300-Villaviciosa, Asturias, Spain²

Received 26 September 2005/ Returned for modification 19 November 2005/ Accepted 8 February 2006

Two large conjugative resistance (R) plasmids from clinical strains of Salmonella enterica serovar Virchow carried a class 2 integron with the 5' conserved sequence (5'CS)-dfrA1-sat1-aadA1-3'CS gene array, which is associated with defective Tn7 transposons. In addition, each contained a different class 1 integron (with 5'CS-aadA1-3'CS or 5'CS-sat-smr-aadA1-3'CS gene arrays) linked to Tn21-Tn9 sequences, and several non-integron-associated R determinants. An intact copy of Tn7 (including the class 2 integron) was present in the chromosome of each strain.

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