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Antimicrobial Agents and Chemotherapy, May 2006, p. 1701-1709, Vol. 50, No. 5
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.5.1701-1709.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

7-O-Malonyl Macrolactin A, a New Macrolactin Antibiotic from Bacillus subtilis Active against Methicillin-Resistant Staphylococcus aureus, Vancomycin-Resistant Enterococci, and a Small-Colony Variant of Burkholderia cepacia

Magally Romero-Tabarez,1 Rolf Jansen,1 Marita Sylla,1 Heinrich Lünsdorf,1 Susanne Häußler,2 Dwi A. Santosa,3,4 Kenneth N. Timmis,1 and Gabriella Molinari1*

Division of Microbiology,1 Cell Biology, German Research Centre for Biotechnology, Braunschweig, Germany,2 Department of Soil Science and Land Resource, Faculty of Agriculture, Bogor Agricultural University,3 Indonesian Center for Biodiversity and Biotechnology, Bogor, Indonesia4

Received 16 July 2005/ Returned for modification 19 August 2005/ Accepted 21 February 2006

We report here the discovery, isolation, and chemical and preliminary biological characterization of a new antibiotic compound, 7-O-malonyl macrolactin A (MMA), produced by a Bacillus subtilis soil isolate. MMA is a bacteriostatic antibiotic that inhibits a number of multidrug-resistant gram-positive bacterial pathogens, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and a small-colony variant of Burkholderia cepacia. MMA-treated staphylococci and enterococci were pseudomulticellular and exhibited multiple asymmetric initiation points of septum formation, indicating that MMA may inhibit a cell division function.

* Corresponding author. Mailing address: Division of Microbiology, German Research Centre for Biotechnology, Mascheroder Weg 1, 38124 Braunschweig, Germany. Phone: 49 531 6181 557. Fax: 49 531 6181 411. E-mail: gmo{at}gbf.de.

Antimicrobial Agents and Chemotherapy, May 2006, p. 1701-1709, Vol. 50, No. 5
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.5.1701-1709.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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