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Antimicrobial Agents and Chemotherapy, May 2006, p. 1859-1860, Vol. 50, No. 5
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.5.1859-1860.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Curcumin-Artemisinin Combination Therapy for Malaria

Dalavaikodihalli Nanjaiah Nandakumar,{dagger} Viswanathan Arun Nagaraj,{dagger} Palakkod Govindan Vathsala,{dagger} Pundi Rangarajan, and Govindarajan Padmanaban*

Department of Biochemistry, Indian Institute of Science, Bangalore 560 012, India

Received 22 December 2005/ Returned for modification 24 January 2006/ Accepted 30 January 2006

Artemisinin and curcumin show an additive interaction in killing Plasmodium falciparum in culture. In vivo, 3 oral doses of curcumin following a single injection of {alpha},ß-arteether to Plasmodium berghei-infected mice are able to prevent recrudescence due to {alpha},ß-arteether monotherapy and ensure almost 100% survival of the animals.

* Corresponding author. Mailing address: Department of Biochemistry, Indian Institute of Science, Bangalore 560 012, India. Phone and fax: 91 080 23601492. E-mail: geepee{at}biochem.iisc.ernet.in.

{dagger} These authors made equal contributions to this study.

Antimicrobial Agents and Chemotherapy, May 2006, p. 1859-1860, Vol. 50, No. 5
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.5.1859-1860.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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  • Cui, L., Miao, J., Cui, L. (2007). Cytotoxic Effect of Curcumin on Malaria Parasite Plasmodium falciparum: Inhibition of Histone Acetylation and Generation of Reactive Oxygen Species. Antimicrob. Agents Chemother. 51: 488-494 [Abstract] [Full Text]  


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