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Antimicrobial Agents and Chemotherapy, May 2006, p. 1861-1864, Vol. 50, No. 5
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.5.1861-1864.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Extended-Spectrum ß-Lactamases and Plasmid-Mediated AmpC Enzymes among Clinical Isolates of Escherichia coli and Klebsiella pneumoniae from Seven Medical Centers in Taiwan

Jing-Jou Yan,1 Po-Ren Hsueh,2 Jang-Jih Lu,3 Feng-Yee Chang,3 Jainn-Ming Shyr,4 Jen-Hsien Wan,5 Yung-Ching Liu,5 Yin-Ching Chuang,6 Yi-Chueh Yang,6 Shih-Ming Tsao,7 Hsiu-Hung Wu,7 Li-Shin Wang,8 Tsuey-Pin Lin,9 Hsiu-Mei Wu,1 Hung-Mo Chen,1 and Jiunn-Jong Wu1*

Departments of Pathology, Internal Medicine, and Medical Laboratory Science and Biotechnology, National Cheng Kung University College of Medicine,1 Chi-Mei Medical Center,6 Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan,9 National Taiwan University Hospital,2 Triservice General Hospital, Taipei,3 Taichung Veterans General Hospital,4 China Medical College Hospital,5 Chung Shan Medical University Hospital, Taichung,7 Buddhist Tzu-Chi General Hospital, Hualien, Taiwan8

Received 28 September 2005/ Returned for modification 13 November 2005/ Accepted 14 February 2006

Production of extended-spectrum ß-lactamases and plasmid-mediated AmpC enzymes was investigated among 291 Escherichia coli and 282 Klebsiella pneumoniae isolates that showed decreased susceptibilities to extended-spectrum cephalosporins from seven Taiwanese medical centers. CTX-M-type and SHV-type enzymes were the most prevalent extended-spectrum ß-lactamases. CMY-2-like and DHA-1-like ß-lactamases were the most prevalent AmpC-type enzymes.

* Corresponding author. Mailing address: Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, No. 1 University Road, Tainan, Taiwan 70101. Phone: 886-6-2353535, ext. 5775. Fax: 886-6-2363956. E-mail: jjwu{at}mail.ncku.edu.tw.

Antimicrobial Agents and Chemotherapy, May 2006, p. 1861-1864, Vol. 50, No. 5
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.5.1861-1864.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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