AAC
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sherertz, R. J.
Right arrow Articles by Raad, I. I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sherertz, R. J.
Right arrow Articles by Raad, I. I.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, May 2006, p. 1865-1868, Vol. 50, No. 5
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.5.1865-1868.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Comparative In Vitro Efficacies of Various Catheter Lock Solutions

Robert J. Sherertz,1* Michael S. Boger,1 Casey A. Collins,1 Lori Mason,2 and Issam I. Raad3

Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina,1 Department of Infection Control, North Carolina Baptist Hospital, Winston-Salem, North Carolina,2 Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M. D. Anderson Cancer Center, Houston, Texas3

Received 17 January 2006/ Accepted 17 February 2006

MEDTA (minocycline-edetate calcium disodium), taurolidine (2%)-polyvinylpyrolidine (5%) (T/PVP), and ethanol as potential catheter lock solutions have a unique mechanism of action, broad-spectrum activity, and anticoagulant properties. Traditional lock solutions minocycline (M), rifampin (R), ciprofloxacin (C), and vancomycin, except pharmacologic concentrations of C and R and of M and R, were less effective than MEDTA and T/PVP.

* Corresponding author. Mailing address: Section on Infectious Diseases, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27517. Phone: (336) 716-4584. Fax: (336) 716-3825. E-mail: sherertz{at}wfubmc.edu.

Antimicrobial Agents and Chemotherapy, May 2006, p. 1865-1868, Vol. 50, No. 5
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.5.1865-1868.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:



Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Clin. Vaccine Immunol. Clin. Microbiol. Rev.
J. Clin. Microbiol. ALL ASM JOURNALS

Copyright © 2006 by the American Society for Microbiology. All rights reserved.