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Antimicrobial Agents and Chemotherapy, May 2006, p. 1869-1871, Vol. 50, No. 5
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.5.1869-1871.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Pharmacokinetics of a New, Orally Available Ceftriaxone Formulation in Physical Complexation with a Cationic Analogue of Bile Acid in Rats

Seulki Lee, Sang Kyoon Kim, Dong Yun Lee, Su Young Chae, and Youngro Byun*

College of Pharmacy, Seoul National University, San 56-1, Shillim-dong, Gwanak-gu, Seoul 151-742, Korea

Received 24 September 2005/ Returned for modification 29 November 2005/ Accepted 11 February 2006

Oral administration of ceftriaxone associated with a bile acid-based new oral carrier, cholylethylenediamine, in 50% propylene glycol to rats at doses of 25 and 50 mg/kg of body weight resulted in a significant increase in intestinal absorption, as evidenced by 55% improvement in the bioavailability, whereas ceftriaxone alone showed a bioavailability of less than 1%.

* Corresponding author. Mailing address: College of Pharmacy, Seoul National University, San 56-1, Shillim-dong, Gwanak-gu, Seoul 151-742, Korea. Phone: 82-2-880-7866. Fax: 82-2-872-7864. E-mail: yrbyun{at}snu.ac.kr.

Antimicrobial Agents and Chemotherapy, May 2006, p. 1869-1871, Vol. 50, No. 5
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.5.1869-1871.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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