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Antimicrobial Agents and Chemotherapy, May 2006, p. 1878-1880, Vol. 50, No. 5
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.5.1878-1880.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Intrapulmonary Penetration of Voriconazole in Patients Receiving an Oral Prophylactic Regimen

Blair Capitano,1,2* Brian A. Potoski,1,2 Shahid Husain,2 Shimin Zhang,1 David L. Paterson,2 Sean M. Studer,3 Kenneth R. McCurry,4 and Raman Venkataramanan1,5

School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania,1 Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania,2 Division of Pulmonary and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania,3 Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania,4 Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania5

Received 6 October 2005/ Returned for modification 4 December 2005/ Accepted 13 February 2006

Voriconazole penetrated well into the pulmonary epithelial lining fluid (ELF) in lung transplant patients receiving oral prophylaxis. The ELF concentrations exceeded those of the plasma, with an average ELF-to-plasma ratio of 11 (±8). A strong association between plasma and ELF concentrations (r2 = 0.95) was noted.

* Corresponding author. Mailing address: School of Pharmacy, University of Pittsburgh, 720 Salk Hall, 3501 Terrace St., Pittsburgh, PA 15261. Phone: (412) 648-9629. Fax: (412) 624-8175. E-mail: capitanob{at}upmc.edu.

Antimicrobial Agents and Chemotherapy, May 2006, p. 1878-1880, Vol. 50, No. 5
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.5.1878-1880.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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