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Antimicrobial Agents and Chemotherapy, May 2006, p. 1881-1883, Vol. 50, No. 5
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.5.1881-1883.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Effect of a Nutritional Supplement on Posaconazole Pharmacokinetics following Oral Administration to Healthy Volunteers

Angela Sansone-Parsons,1* Gopal Krishna,1 Angela Calzetta,1 David Wexler,1 Bhavna Kantesaria,1 Mitchell A. Rosenberg,2 and Marc A. Saltzman2

Schering-Plough Research Institute, Kenilworth, New Jersey,1 Parkway Research Center, Inc., North Miami, Florida2

Received 3 October 2005/ Returned for modification 7 November 2005/ Accepted 13 February 2006

We conducted a randomized, crossover study in healthy adults to examine the effects of a nutritional supplement (Boost Plus) on posaconazole pharmacokinetics. In this study, coadministration of posaconazole with Boost Plus increased the maximum concentration of posaconazole in serum and area under the concentration-time curve from 0 to 72 h values 3.4- and 2.6-fold, respectively, compared to those for the fasted state.

* Corresponding author. Mailing address: Schering-Plough Research Institute, K-15-4-4455, 2015 Galloping Hill Rd., Kenilworth, NJ 07033. Phone: (908) 740-4093. Fax: (908) 740-2169. E-mail: angela.sansone{at}spcorp.com.

Antimicrobial Agents and Chemotherapy, May 2006, p. 1881-1883, Vol. 50, No. 5
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.5.1881-1883.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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