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Antimicrobial Agents and Chemotherapy, May 2006, p. 1893-1895, Vol. 50, No. 5
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.5.1893-1895.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Selection of Plasmodium falciparum pfmdr1 Alleles following Therapy with Artemether-Lumefantrine in an Area of Uganda where Malaria Is Highly Endemic

Christian Dokomajilar,1 Samuel L. Nsobya,2 Bryan Greenhouse,1 Philip J. Rosenthal,1 and Grant Dorsey1*

Department of Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, California,1 Department of Medicine, Makerere University, Kampala, Uganda2

Received 8 February 2006/ Returned for modification 1 March 2006/ Accepted 8 March 2006

Polymorphisms in the Plasmodium falciparum pfmdr1 gene were assayed in pretreatment samples and in samples from patients reinfected following therapy with artemether-lumefantrine. The pfmdr1 alleles 86N, 184F, and 1246D significantly increased in prevalence after treatment. All samples had a single pfmdr1 copy. Treatment with artemether-lumefantrine selects for polymorphisms that may alter antimalarial drug response.

* Corresponding author. Mailing address: University of California, San Francisco, Box 0811, San Francisco, CA 94143. Phone: (415) 206-4680. Fax: (415) 648-8425. E-mail: gdorsey{at}medsfgh.ucsf.edu.

Antimicrobial Agents and Chemotherapy, May 2006, p. 1893-1895, Vol. 50, No. 5
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.5.1893-1895.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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