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Antimicrobial Agents and Chemotherapy, May 2006, p. 1900-1902, Vol. 50, No. 5
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.5.1900-1902.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Significance of Mutations in embB Codon 306 for Prediction of Ethambutol Resistance in Clinical Mycobacterium tuberculosis Isolates

Claudia Plinke, Sabine Rüsch-Gerdes, and Stefan Niemann*

Forschungszentrum Borstel, National Reference Center for Mycobacteria, D-23845 Borstel, Germany

Received 11 January 2006/ Returned for modification 20 January 2006/ Accepted 21 February 2006

We analyzed 159 Mycobacterium tuberculosis isolates (101 ethambutol [EMB]-resistant strains, 33 multidrug-resistant but not EMB-resistant strains, and 25 fully susceptible strains) for the presence of mutations in embB codon 306 (embB306). Mutations were detected only in EMB-resistant strains (n = 69; 68%), thus confirming the significance of embB306 mutations for the prediction of resistance to EMB.

* Corresponding author. Mailing address: Forschungszentrum Borstel, National Reference Center for Mycobacteria, Parkallee 18, D-23845 Borstel, Germany. Phone: (49) 4537-188762. Fax: (49) 4537-188311. E-mail: sniemann{at}fz-borstel.de.

Antimicrobial Agents and Chemotherapy, May 2006, p. 1900-1902, Vol. 50, No. 5
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.5.1900-1902.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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