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Antimicrobial Agents and Chemotherapy, June 2006, p. 2210-2213, Vol. 50, No. 6
0066-4804/06/$08.00+0     doi:10.1128/AAC.01447-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Impact of Human Immunodeficiency Virus Type 1 Subtype C on Drug Resistance Mutations in Patients from Botswana Failing a Nelfinavir-Containing Regimen

Florence Doualla-Bell,1,2 Ava Avalos,1,3 Tendani Gaolathe,1,3 Madisa Mine,1,3 Simani Gaseitsiwe,1 Ndwapi Ndwapi,1,3 Vladimir A. Novitsky,4 Bluma Brenner,2 Maureen Oliveira,2 Daniella Moisi,2 Howard Moffat,3 Ibou Thior,1 Max Essex,4 and Mark A. Wainberg2*

Botswana-Harvard School of Public Health AIDS Initiative Partnership for HIV Research and Education, Gaborone, Botswana,1 McGill University AIDS Centre, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada,2 Infectious Disease Care Clinic, Princess Marina Hospital, Gaborone, Botswana,3 Harvard School of Public Health, Boston, Massachusetts4

Received 9 November 2005/ Returned for modification 9 January 2006/ Accepted 23 March 2006

Among 16 human immunodeficiency virus-infected (subtype C) Batswana patients who failed nelfinavir (NFV)-containing regimens, the most prevalent mutation observed was D30N (54%), followed by L90M (31%). L89I, K20T/I, and E35D polymorphic changes were also identified. These findings suggest that subtype C viruses in Botswana may develop resistance to NFV via subtype-specific pathways.

* Corresponding author. Mailing address: McGill AIDS Centre, Lady Davis Institute for Medical Research, 3755 chemin de la Côte-Ste-Catherine, Montreal (Quebec) H3T 1E2, Canada. Phone: (514) 340 8260. Fax: (514) 340 7537. E-mail: mark.wainberg{at}mcgill.ca.

Antimicrobial Agents and Chemotherapy, June 2006, p. 2210-2213, Vol. 50, No. 6
0066-4804/06/$08.00+0     doi:10.1128/AAC.01447-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Doualla-Bell, F., Avalos, A., Brenner, B., Gaolathe, T., Mine, M., Gaseitsiwe, S., Oliveira, M., Moisi, D., Ndwapi, N., Moffat, H., Essex, M., Wainberg, M. A. (2006). High Prevalence of the K65R Mutation in Human Immunodeficiency Virus Type 1 Subtype C Isolates from Infected Patients in Botswana Treated with Didanosine-Based Regimens. Antimicrob. Agents Chemother. 50: 4182-4185 [Abstract] [Full Text]  


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