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Antimicrobial Agents and Chemotherapy, June 2006, p. 2214-2216, Vol. 50, No. 6
0066-4804/06/$08.00+0     doi:10.1128/AAC.01610-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Caspofungin Susceptibility in Aspergillus and Non-Aspergillus Molds: Inhibition of Glucan Synthase and Reduction of ß-D-1,3 Glucan Levels in Culture

Jennifer Nielsen Kahn,* Ming-Jo Hsu, Fred Racine, Robert Giacobbe, and Mary Motyl

Infectious Disease Research, Merck and Co., P.O. Box 2000, Rahway, New Jersey 07065-0900

Received 19 December 2005/ Returned for modification 24 January 2006/ Accepted 12 March 2006

Caspofungin inhibits synthesis of ß-D-1,3 glucan, essential to cell walls in Candida and Aspergillus spp., but activity against less common molds is largely uncharacterized. We demonstrate that caspofungin inhibits ß-D-1,3 glucan synthesis and reduces in vitro growth of clinical isolates from the genera Alternaria, Curvularia, Scedosporium, Acremonium, Bipolaris, and Trichoderma.

* Corresponding author. Mailing address: Infectious Disease Research, Merck and Co., 80Y-210, P.O. Box 2000, Rahway, NJ 07065-0900. Phone: (732) 594-6799. Fax: (732) 594-1399. E-mail: jennifer_nielsen_kahn{at}merck.com.

Antimicrobial Agents and Chemotherapy, June 2006, p. 2214-2216, Vol. 50, No. 6
0066-4804/06/$08.00+0     doi:10.1128/AAC.01610-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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