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Caspofungin Susceptibility in Aspergillus and Non-Aspergillus Molds: Inhibition of Glucan Synthase and Reduction of ß-D-1,3 Glucan Levels in Culture

Infectious Disease Research, Merck and Co., P.O. Box 2000, Rahway, New Jersey 07065-0900

Received 19 December 2005/ Returned for modification 24 January 2006/ Accepted 12 March 2006

Caspofungin inhibits synthesis of ß-D-1,3 glucan, essential to cell walls in Candida and Aspergillus spp., but activity against less common molds is largely uncharacterized. We demonstrate that caspofungin inhibits ß-D-1,3 glucan synthesis and reduces in vitro growth of clinical isolates from the genera Alternaria, Curvularia, Scedosporium, Acremonium, Bipolaris, and Trichoderma.

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