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Antimicrobial Agents and Chemotherapy, June 2006, p. 2225-2227, Vol. 50, No. 6
0066-4804/06/$08.00+0     doi:10.1128/AAC.01559-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Diminished Macrophage Inflammatory Response to Staphylococcus aureus Isolates Exposed to Daptomycin versus Vancomycin or Oxacillin

B. Keith English,1,3* Erik M. Maryniw,3 Ajay J. Talati,1,2,3 and Elizabeth A. Meals1,3

Departments of Pediatrics,1 Obstetrics-Gynecology, University of Tennessee Health Science Center,2 Children's Foundation Research Center at Le Bonheur Children's Medical Center, Memphis, Tennessee 381033

Received 7 December 2005/ Returned for modification 25 January 2006/ Accepted 10 March 2006

Exposure of any of six clinical isolates of Staphylococcus aureus to daptomycin alone or in combination with vancomycin or oxacillin (compared with vancomycin or oxacillin alone) led to a dampened macrophage inflammatory response with diminished tumor necrosis factor secretion and reduced accumulation of inducible nitric oxide synthase protein.

* Corresponding author. Mailing address: Children's Foundation Research Center at Le Bonheur Children's Medical Center, Room 301 WPT, 50 North Dunlap Street, Memphis, TN 38103. Phone: (901) 572-5376. Fax: (901) 572-5036. E-mail: kenglish{at}utmem.edu.

Antimicrobial Agents and Chemotherapy, June 2006, p. 2225-2227, Vol. 50, No. 6
0066-4804/06/$08.00+0     doi:10.1128/AAC.01559-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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