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Antimicrobial Agents and Chemotherapy, June 2006, p. 2231-2233, Vol. 50, No. 6
0066-4804/06/$08.00+0     doi:10.1128/AAC.00761-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Synergistic In Vitro Antiretroviral Activity of a Humanized Monoclonal Anti-CD4 Antibody (TNX-355) and Enfuvirtide (T-20)

Xing-Quan Zhang,1 Meredith Sorensen,2 Michael Fung,3 and Robert T. Schooley1*

University of California, San Diego, San Diego, California 92093,1 Dartmouth Medical School, Hanover, New Hampshire 03755,2 Tanox, Inc., Houston, Texas 770253

Received 15 June 2005/ Returned for modification 13 September 2005/ Accepted 23 March 2006

Recently, antiretroviral agents directed at several steps involved in viral entry have been shown to reduce viral replication in vitro and in vivo. We have demonstrated a high level of in vitro synergistic antiretroviral activity for two entry inhibitors that are directed at sequential steps in the entry process.

* Corresponding author. Mailing address: University of California, San Diego, San Diego, CA 92093. Phone: (858) 822-0216. Fax: (858) 822-5362. E-mail: rschooley{at}ucsd.edu.

Antimicrobial Agents and Chemotherapy, June 2006, p. 2231-2233, Vol. 50, No. 6
0066-4804/06/$08.00+0     doi:10.1128/AAC.00761-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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