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Antimicrobial Agents and Chemotherapy, June 2006, p. 2234-2236, Vol. 50, No. 6
0066-4804/06/$08.00+0     doi:10.1128/AAC.01600-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Biological, Biochemical, and Molecular Characterization of a New Clinical Trichophyton rubrum Isolate Resistant to Terbinafine

Colin S. Osborne,* Ingrid Leitner, Bettina Hofbauer, Ceri A. Fielding,{dagger} Bertrand Favre,{ddagger} and Neil S. Ryder§

Infectious Diseases, Novartis Institutes for BioMedical Research, 1235 Vienna, Austria

Received 16 December 2005/ Returned for modification 24 January 2006/ Accepted 26 March 2006

We have characterized a new clinical strain of Trichophyton rubrum highly resistant to terbinafine but exhibiting normal susceptibility to drugs with other mechanisms of action. Resistance to terbinafine in this strain is caused by a missense mutation in the squalene epoxidase gene leading to the amino acid substitution F397L.

* Corresponding author. Mailing address: Infectious Diseases, Room 8654, Novartis Institutes for BioMedical Research, Inc., 100 Technology Square, Cambridge, MA 02139. Phone: (617) 871 3142. Fax: (617) 871 7047. E-mail: colin.osborne{at}novartis.com.

{dagger} Present address: Infection and Immunity, University of Wales College of Medicine, Henry Wellcome Research Institute, Heath Park, Cardiff CF14 4XX, United Kingdom.

{ddagger} Present address: Department of Dermatology, Hospital of Beaumont CHUV, 1011 Lausanne, Switzerland.

§ Present address: Infectious Diseases, Novartis Institutes for Biomedical Research, Inc., Cambridge, MA 02139.

Antimicrobial Agents and Chemotherapy, June 2006, p. 2234-2236, Vol. 50, No. 6
0066-4804/06/$08.00+0     doi:10.1128/AAC.01600-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Ruckenstuhl, C., Lang, S., Poschenel, A., Eidenberger, A., Baral, P. K., Kohut, P., Hapala, I., Gruber, K., Turnowsky, F. (2007). Characterization of Squalene Epoxidase of Saccharomyces cerevisiae by Applying Terbinafine-Sensitive Variants. Antimicrob. Agents Chemother. 51: 275-284 [Abstract] [Full Text]  


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