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Antimicrobial Agents and Chemotherapy, June 2006, p. 2237-2239, Vol. 50, No. 6
0066-4804/06/$08.00+0     doi:10.1128/AAC.01118-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Idebenone Acts against Growth of Helicobacter pylori by Inhibiting Its Respiration

Sakiko Inatsu,1 Ayumi Ohsaki,2 and Kumiko Nagata1*

Department of Microbiology, Hyogo College of Medicine, Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan,1 Division of Medical Chemistry, Institute for Medical and Dental Engineering, Tokyo Medical and Dental University, Kanda Chiyoda-ku, Tokyo 101-0062, Japan2

Received 7 September 2005/ Returned for modification 5 October 2005/ Accepted 23 March 2006

Growth of Helicobacter pylori was inhibited by the quinones, idebenone, duroquinone, menadione, juglone, and coenzyme Q1 at low concentrations of 0.8 to 3.2 µg/ml. Idebenone specifically inhibited H. pylori growth by inhibiting respiration and decreasing the cellular ATP level. The respiratory inhibition was accompanied by reduction of idebenone by the H. pylori cells.

* Corresponding author. Mailing address: Department of Microbiology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan. Phone: 81-0798-45-6548. Fax: 81-0798-40-9162. E-mail: kunagata{at}hyo-med.ac.jp.

Antimicrobial Agents and Chemotherapy, June 2006, p. 2237-2239, Vol. 50, No. 6
0066-4804/06/$08.00+0     doi:10.1128/AAC.01118-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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