This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Inatsu, S.
Right arrow Articles by Nagata, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Inatsu, S.
Right arrow Articles by Nagata, K.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, June 2006, p. 2237-2239, Vol. 50, No. 6
0066-4804/06/$08.00+0     doi:10.1128/AAC.01118-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Idebenone Acts against Growth of Helicobacter pylori by Inhibiting Its Respiration

Sakiko Inatsu,1 Ayumi Ohsaki,2 and Kumiko Nagata1*

Department of Microbiology, Hyogo College of Medicine, Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan,1 Division of Medical Chemistry, Institute for Medical and Dental Engineering, Tokyo Medical and Dental University, Kanda Chiyoda-ku, Tokyo 101-0062, Japan2

Received 7 September 2005/ Returned for modification 5 October 2005/ Accepted 23 March 2006

Growth of Helicobacter pylori was inhibited by the quinones, idebenone, duroquinone, menadione, juglone, and coenzyme Q1 at low concentrations of 0.8 to 3.2 µg/ml. Idebenone specifically inhibited H. pylori growth by inhibiting respiration and decreasing the cellular ATP level. The respiratory inhibition was accompanied by reduction of idebenone by the H. pylori cells.

* Corresponding author. Mailing address: Department of Microbiology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan. Phone: 81-0798-45-6548. Fax: 81-0798-40-9162. E-mail: kunagata{at}hyo-med.ac.jp.

Antimicrobial Agents and Chemotherapy, June 2006, p. 2237-2239, Vol. 50, No. 6
0066-4804/06/$08.00+0     doi:10.1128/AAC.01118-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»