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Antimicrobial Agents and Chemotherapy, June 2006, p. 2240-2243, Vol. 50, No. 6
0066-4804/06/$08.00+0     doi:10.1128/AAC.00045-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Efficacy of Voriconazole in a Guinea Pig Model of Invasive Trichosporonosis

Carolina Serena, Félix Gilgado, Marçal Mariné, F. Javier Pastor, and Josep Guarro*

Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Reus, Spain

Received 11 January 2006/ Returned for modification 13 February 2006/ Accepted 15 March 2006

We have evaluated the efficacy of voriconazole (VRC) in a systemic infection by Trichosporon asahii in immunosuppressed guinea pigs. VRC was more effective than amphotericin B in prolonging survival and reducing tissue burden. The best results were obtained with VRC at 10 mg/kg of body weight/day.

* Corresponding author. Mailing address: Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili, Carrer Sant Llorenç, 21.43201 Reus, Spain. Phone: 977-759359. Fax: 977-759322. E-mail: josep.guarro{at}urv.net.

Antimicrobial Agents and Chemotherapy, June 2006, p. 2240-2243, Vol. 50, No. 6
0066-4804/06/$08.00+0     doi:10.1128/AAC.00045-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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