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Antimicrobial Agents and Chemotherapy, June 2006, p. 2248-2250, Vol. 50, No. 6
0066-4804/06/$08.00+0     doi:10.1128/AAC.00162-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

In Vitro Activities of 10 Combinations of Antifungal Agents against the Multiresistant Pathogen Scopulariopsis brevicaulis

Manuel Cuenca-Estrella,* Alicia Gomez-Lopez, Maria J. Buitrago, Emilia Mellado, Guillermo Garcia-Effron, and Juan L. Rodriguez-Tudela

Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain

Received 7 February 2006/ Returned for modification 9 March 2006/ Accepted 14 March 2006

The activities of 10 combinations of antifungal agents against 25 clinical isolates of Scopulariopsis brevicaulis were tested by the checkerboard technique. An average indifferent effect was detected for all combinations. Synergy was observed for some isolates and combinations, particularly with posaconazole-terbinafine (68% of strains), amphotericin B-caspofungin (60%), and posaconazole-caspofungin (48%).

* Corresponding author. Mailing address: Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Ctra Majadahonda-Pozuelo Km 2, 28220 Majadahonda (Madrid), Spain. Phone: 34-91-5097961. Fax: 34-91-5097966. E-mail: mcuenca-estrella{at}isciii.es.

Antimicrobial Agents and Chemotherapy, June 2006, p. 2248-2250, Vol. 50, No. 6
0066-4804/06/$08.00+0     doi:10.1128/AAC.00162-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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