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Antimicrobial Agents and Chemotherapy, June 2006, p. 2251-2254, Vol. 50, No. 6
0066-4804/06/$08.00+0     doi:10.1128/AAC.00123-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Fluoroquinolone-Resistant Urinary Isolates of Escherichia coli from Outpatients Are Frequently Multidrug Resistant: Results from the North American Urinary Tract Infection Collaborative Alliance-Quinolone Resistance Study

James A. Karlowsky,1,2* Daryl J. Hoban,1,2 Melanie R. DeCorby,2 Nancy M. Laing,2 and George G. Zhanel2

Department of Clinical Microbiology, Health Sciences Centre/Diagnostic Services of Manitoba,1 Department of Medical Microbiology and Infectious Diseases, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada2

Received 31 January 2006/ Returned for modification 6 March 2006/ Accepted 21 March 2006

Ciprofloxacin-resistant Escherichia coli isolates (n = 1,858) from outpatient midstream urine specimens at 40 North American clinical laboratories in 2004 to 2005 were frequently resistant to ampicillin (79.8% of isolates) and trimethoprim-sulfamethoxazole (66.5%); concurrent resistance to cefdinir (9.0%) or nitrofurantoin (4.0%) was less common. Only 10.8% of isolates were resistant to ciprofloxacin alone. Fluoroquinolone-resistant isolates of E. coli from urine were frequently multidrug resistant.


* Corresponding author. Mailing address: Department of Clinical Microbiology, Health Sciences Centre, MS673C, 820 Sherbrook Street, Winnipeg, Manitoba R3A 1R9, Canada. Phone: (204) 787-4597. Fax: (204) 787-4699. E-mail: jkarlowsky{at}hsc.mb.ca.


Antimicrobial Agents and Chemotherapy, June 2006, p. 2251-2254, Vol. 50, No. 6
0066-4804/06/$08.00+0     doi:10.1128/AAC.00123-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.




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