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Antimicrobial Agents and Chemotherapy, June 2006, p. 2255-2257, Vol. 50, No. 6
0066-4804/06/$08.00+0     doi:10.1128/AAC.00011-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

In Vitro Activities of DX-619 and Comparison Quinolones against Gram-Positive Cocci

Paul A. Wickman,* Jennifer A. Black, Ellen Smith Moland, and Kenneth S. Thomson

Creighton University School of Medicine, Department of Medical Microbiology and Immunology, Center for Research in Anti-Infectives and Biotechnology, Omaha, Nebraska

Received 4 January 2006/ Accepted 19 March 2006

The in vitro activity of the novel quinolone DX-619 was compared to those of currently available quinolones against U.S. clinical isolates of Staphylococcus aureus, coagulase-negative staphylococci, Enterococcus spp., Streptococcus pyogenes, and Streptococcus pneumoniae. DX-619 was the most potent quinolone overall, indicating possible utility as an anti-gram-positive quinolone.

* Corresponding author. Mailing address: Center for Research in Anti-Infectives and Biotechnology, Department of Medical Microbiology and Immunology, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178. Phone: (402) 280-2921. Fax: (402) 280-1875. E-mail: pwickman{at}creighton.edu.

Antimicrobial Agents and Chemotherapy, June 2006, p. 2255-2257, Vol. 50, No. 6
0066-4804/06/$08.00+0     doi:10.1128/AAC.00011-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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