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Antimicrobial Agents and Chemotherapy, June 2006, p. 2258-2260, Vol. 50, No. 6
0066-4804/06/$08.00+0     doi:10.1128/AAC.01513-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Effect of Porins and Plasmid-Mediated AmpC ß-Lactamases on the Efficacy of ß-Lactams in Rat Pneumonia Caused by Klebsiella pneumoniae

Emma Padilla,1,3 Diana Alonso,3 Antonio Doménech-Sánchez,3 Cristina Gomez,2 José Luis Pérez,1,3 Sebastián Albertí,3 and Nuria Borrell1,3*

Servicio de Microbiología,1 Anatomía Patológica, Hospital Son Dureta, IUNICS,2 Departmento de Biología, Universitat de les Illes Balears, Palma de Mallorca, Spain3

Received 25 November 2005/ Returned for modification 12 January 2006/ Accepted 21 March 2006

The in vivo activities of imipenem, meropenem, and cefepime were studied in a model of rat pneumonia caused by a plasmid-mediated AmpC ß-lactamase ACT-1-producing Klebsiella pneumoniae strain (K. pneumoniae strain 12) and a derivative porin-deficient mutant (K. pneumoniae strain 12dp). No differences between these activities were seen with K. pneumoniae 12. Only meropenem showed an activity slightly better than that of imipenem with K. pneumoniae 12dp.

* Corresponding author. Mailing address: Department of Microbiology, Hospital Son Dureta, Andrea Doria no. 55, 07014 Palma de Mallorca, Illes Balears, Spain. Phone: 34-71-175238. Fax: 34-71-175185. E-mail: nborrell{at}hsd.es.

Antimicrobial Agents and Chemotherapy, June 2006, p. 2258-2260, Vol. 50, No. 6
0066-4804/06/$08.00+0     doi:10.1128/AAC.01513-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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