This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Padilla, E.
Right arrow Articles by Borrell, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Padilla, E.
Right arrow Articles by Borrell, N.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, June 2006, p. 2258-2260, Vol. 50, No. 6
0066-4804/06/$08.00+0     doi:10.1128/AAC.01513-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Effect of Porins and Plasmid-Mediated AmpC ß-Lactamases on the Efficacy of ß-Lactams in Rat Pneumonia Caused by Klebsiella pneumoniae

Emma Padilla,1,3 Diana Alonso,3 Antonio Doménech-Sánchez,3 Cristina Gomez,2 José Luis Pérez,1,3 Sebastián Albertí,3 and Nuria Borrell1,3*

Servicio de Microbiología,1 Anatomía Patológica, Hospital Son Dureta, IUNICS,2 Departmento de Biología, Universitat de les Illes Balears, Palma de Mallorca, Spain3

Received 25 November 2005/ Returned for modification 12 January 2006/ Accepted 21 March 2006

The in vivo activities of imipenem, meropenem, and cefepime were studied in a model of rat pneumonia caused by a plasmid-mediated AmpC ß-lactamase ACT-1-producing Klebsiella pneumoniae strain (K. pneumoniae strain 12) and a derivative porin-deficient mutant (K. pneumoniae strain 12dp). No differences between these activities were seen with K. pneumoniae 12. Only meropenem showed an activity slightly better than that of imipenem with K. pneumoniae 12dp.

* Corresponding author. Mailing address: Department of Microbiology, Hospital Son Dureta, Andrea Doria no. 55, 07014 Palma de Mallorca, Illes Balears, Spain. Phone: 34-71-175238. Fax: 34-71-175185. E-mail: nborrell{at}hsd.es.

Antimicrobial Agents and Chemotherapy, June 2006, p. 2258-2260, Vol. 50, No. 6
0066-4804/06/$08.00+0     doi:10.1128/AAC.01513-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Jacoby, G. A. (2009). AmpC {beta}-Lactamases. Clin. Microbiol. Rev. 22: 161-182 [Abstract] [Full Text]  
  • Vimont, S., Aubert, D., Mazoit, J.-X., Poirel, L., Nordmann, P. (2007). Broad-spectrum {beta}-lactams for treating experimental peritonitis in mice due to Escherichia coli producing plasmid-encoded cephalosporinases. J Antimicrob Chemother 60: 1045-1050 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»