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Antimicrobial Agents and Chemotherapy, July 2006, p. 2522-2524, Vol. 50, No. 7
0066-4804/06/$08.00+0     doi:10.1128/AAC.00148-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Emergence of a Candida krusei Isolate with Reduced Susceptibility to Caspofungin during Therapy

Morgan Hakki,1,2 Janet F. Staab,1 and Kieren A. Marr1,2*

Program in Infectious Diseases, Fred Hutchinson Cancer Research Center,1 Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington 981092

Received 3 February 2006/ Returned for modification 14 February 2006/ Accepted 27 April 2006

Clinical failure associated with reduced susceptibility to caspofungin has been described in Candida albicans and C. parapsilosis. We report a case of Candida krusei infection that progressed despite caspofungin therapy. Reduced microbial susceptibility to all three echinocandins (caspofungin, anidulafungin, and micafungin) was noted but was not associated with mutations in FKS1.

* Corresponding author. Mailing address: Fred Hutchinson Cancer Research Center, Program in Infectious Diseases, 1100 Fairview Ave. N., MS D3-100, Seattle, WA 98109. Phone: (206) 667-6702. Fax: (206) 667-4411. E-mail: kmarr{at}fhcrc.org.

Antimicrobial Agents and Chemotherapy, July 2006, p. 2522-2524, Vol. 50, No. 7
0066-4804/06/$08.00+0     doi:10.1128/AAC.00148-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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