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Antimicrobial Agents and Chemotherapy, July 2006, p. 2525-2529, Vol. 50, No. 7
0066-4804/06/$08.00+0     doi:10.1128/AAC.01489-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Activities of Alkoxyalkyl Esters of Cidofovir (CDV), Cyclic CDV, and (S)-9-(3-Hydroxy-2-Phosphonylmethoxypropyl)Adenine against Orthopoxviruses in Cell Monolayers and in Organotypic Cultures

Rega Institute for Medical Research, K.U. Leuven, Minderbroedersstraat 10, Leuven, Belgium,¹ Department of Medicine, Division of Infectious Disease, University of California, San Diego, La Jolla, California 92093-0676,² Pathology Department, U.Z. Leuven, Minderbroedersstraat 12, Leuven, Belgium,³ Dipartimento di Sanita Pubblica Veterinaria e Patologia Animale, Alma Mater Studiorum, Bologna, via Tolara di Sopra 50, 40064 Ozzano Emilia, Bologna, Italy⁴

Received 18 November 2005/ Returned for modification 24 January 2006/ Accepted 30 March 2006

The potencies of several alkoxyalkyl esters of acyclic nucleoside phosphonates against vaccinia virus and cowpox virus were evaluated in cell monolayers and three-dimensional epithelial raft cultures. Prodrugs were at least 20-fold more active than their parent compounds. Octadecycloxyethyl-(S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine emerged as the most potent derivative.

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