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Antimicrobial Agents and Chemotherapy, July 2006, p. 2530-2532, Vol. 50, No. 7
0066-4804/06/$08.00+0     doi:10.1128/AAC.00238-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Activities of Ceftobiprole and Other ß-Lactams against Streptococcus pneumoniae Clinical Isolates from the United States with Defined Substitutions in Penicillin-Binding Proteins PBP 1a, PBP 2b, and PBP 2x

Johnson & Johnson Pharmaceutical Research & Development, LLC, Raritan, New Jersey

Received 24 February 2006/ Returned for modification 12 April 2006/ Accepted 20 April 2006

The activities of ceftobiprole and other ß-lactams were examined with 30 Streptococcus pneumoniae isolates containing multiple pbp1a, pbp2b, and pbp2x mutations. The highest ceftobiprole MIC was 1 µg/ml, while the comparator MICs were 16 to 64 µg/ml. Fifty percent inhibitory concentrations for penicillin-binding protein 2x were 0.5 µg/ml (ceftobiprole) and 4 µg/ml (ceftriaxone) in a penicillin- and ceftriaxone-resistant isolate.

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