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Antimicrobial Agents and Chemotherapy, July 2006, p. 2533-2536, Vol. 50, No. 7
0066-4804/06/$08.00+0     doi:10.1128/AAC.00187-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

A Phe389Leu Substitution in ErgA Confers Terbinafine Resistance in Aspergillus fumigatus

E. M. F. Rocha,1,2,3 R. E. Gardiner,1 S. Park,1 N. M. Martinez-Rossi,2,3 and D. S. Perlin1*

Public Health Research Institute, International Center for Public Health, Newark, New Jersey 07103-3535,1 Departamento de Genética, Faculdade de Medicina de Ribeirao Preto (FMRP), Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil,2 Departamento de Genética e Bioquímica, Universidade Federal de Uberlândia (UFU), Uberlândia, MG, Brazil3

Received 10 February 2006/ Returned for modification 24 March 2006/ Accepted 25 April 2006

Replacement of phenylalanine with leucine at position 391 in squalene epoxidase was identified as being responsible for terbinafine resistance in mutants of Aspergillus nidulans. The equivalent mutation was engineered into the ergA gene of Aspergillus fumigatus, resulting in an F389L substitution that also conferred resistance to this pathogenic mold.

* Corresponding author. Mailing address: PHRI, International Center for Public Health, 225 Warren St., Newark, NJ 07103. Phone: (973) 854-3200. Fax: (973) 854-3101. E-mail: perlin{at}phri.org.

Antimicrobial Agents and Chemotherapy, July 2006, p. 2533-2536, Vol. 50, No. 7
0066-4804/06/$08.00+0     doi:10.1128/AAC.00187-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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