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Antimicrobial Agents and Chemotherapy, July 2006, p. 2537-2540, Vol. 50, No. 7
0066-4804/06/$08.00+0     doi:10.1128/AAC.00071-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Effect of a Selective Decontamination of the Digestive Tract Regimen Including Parenteral Cefepime on Establishment of Intestinal Colonization with Vancomycin-Resistant Enterococcus spp. and Klebsiella pneumoniae in Mice

Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania,¹ Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio,² Infectious Diseases Section, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio³

Received 16 January 2006/ Returned for modification 15 March 2006/ Accepted 12 April 2006

In mice, a selective decontamination of the digestive tract regimen consisting of orogastric tobramycin, polymyxin E, and amphotericin B in combination with subcutaneous cefepime inhibited gram-negative bacilli, including Klebsiella pneumoniae, and did not promote vancomycin-resistant Enterococcus spp. (VRE) colonization. However, concurrent administration of subcutaneous ampicillin-sulbactam resulted in promotion of VRE.