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Antimicrobial Agents and Chemotherapy, July 2006, p. 2544-2546, Vol. 50, No. 7
0066-4804/06/$08.00+0     doi:10.1128/AAC.00609-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Common Region CR1 for Expression of Antibiotic Resistance Genes

Jose-Manuel Rodriguez-Martinez,1,2 Laurent Poirel,1 Rafael Canton,3 and Patrice Nordmann1*

Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, Université Paris Sud, K.-Bicêtre, France,1 University Hospital Virgen Macarena, University of Sevilla, Sevilla,2 Servicio de Microbiologia, Hospital Universitario Ramon y Cajal, Madrid, Spain3

Received 16 May 2005/ Returned for modification 29 July 2005/ Accepted 10 April 2006

The CR1 element defined by an orf513 gene encoding a putative recombinase and a recombination crossover site has been identified upstream of several antibiotic resistance genes in Enterobacteriaceae. This CR1 element was shown to bring promoter sequences that play a role in the expression of unrelated antibiotic resistance genes.

* Corresponding author. Mailing address: Service de Bactériologie-Virologie, Hôpital de Bicêtre78, rue du General Leclerc, 94275 Le Kremlin-Bicêtre, France. Phone: 33-1-45-21-36-32. Fax: 33-1-45-21-63-40. E-mail: nordmann.patrice{at}bct.ap-hop-paris.fr.

Antimicrobial Agents and Chemotherapy, July 2006, p. 2544-2546, Vol. 50, No. 7
0066-4804/06/$08.00+0     doi:10.1128/AAC.00609-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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