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Antimicrobial Agents and Chemotherapy, July 2006, p. 2547-2549, Vol. 50, No. 7
0066-4804/06/$08.00+0     doi:10.1128/AAC.01501-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

In Vitro and In Vivo Assessment of Linezolid Combined with Ertapenem: a Highly Synergistic Combination against Methicillin-Resistant Staphylococcus aureus

Cedric Jacqueline, Jocelyne Caillon,* Olivier Grossi, Virginie Le Mabecque, Anne-Françoise Miegeville, Denis Bugnon, Eric Batard, and Gilles Potel

Laboratoire d'Antibiologie (UPRES EA 3826), UER de Médecine, Nantes, France

Received 22 November 2005/ Returned for modification 25 January 2006/ Accepted 12 April 2006

Linezolid in combination with ertapenem showed in vitro synergy against methicillin-resistant Staphylococcus aureus strains. We confirmed this interaction in vivo by using a rabbit endocarditis experimental model and simulation of the human pharmacokinetics in animals for both antibiotics. Linezolid plus ertapenem exhibited highly synergistic activity in vivo after 4 days of treatment.

* Corresponding author. Mailing address: Laboratoire d'Antibiologie (UPRES EA 3826), UER de Médecine, 1 rue Gaston Veil, 44035 Nantes, Cedex 01, France. Phone and fax: (33) 240-41-2854. E-mail: jocelyne.caillon{at}univ-nantes.fr.

Antimicrobial Agents and Chemotherapy, July 2006, p. 2547-2549, Vol. 50, No. 7
0066-4804/06/$08.00+0     doi:10.1128/AAC.01501-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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