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Polyphenols Reduce Gastritis Induced by Helicobacter pylori Infection or VacA Toxin Administration in Mice

Chiron s.r.l., Research Center, Siena,¹ Department of Biomedical Sciences, University of Padova, Padova,² CNR Institute of Neuroscience, Section for Biomembranes, Padova,³ Department of Veterinary Science, University of Camerino, Matelica, Italy⁴

Received 11 August 2005/ Returned for modification 30 December 2005/ Accepted 12 April 2006

Helicobacter pylori colonizes the human gastric mucosa, causing inflammation that leads to atrophic gastritis, and it can cause peptic ulcer and gastric cancer. We show that polyphenol administration to mice experimentally infected by H. pylori or treated with VacA toxin can limit gastric epithelium damage, an effect that may be linked to VacA inhibition.