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Antimicrobial Agents and Chemotherapy, July 2006, p. 2553-2556, Vol. 50, No. 7
0066-4804/06/$08.00+0     doi:10.1128/AAC.00092-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Risk Factors for Selection of the L74I Reverse Transcriptase Mutation in Human Immunodeficiency Virus Type 1-Infected Patients

Marc Wirden,1,4* Bénédicte Roquebert,4 Anne Derache,4 Anne Simon,2 Claudine Duvivier,3 Jade Ghosn,3 Stephanie Dominguez,3 Véronique Boutonnet,1 Zaina Ait-Arkoub,1 Christine Katlama,3 Vincent Calvez,1,4 and Anne-Genevieve Marcelin1,4

Departments of Virology,1 Internal Medicine,2 Infectious Diseases, Pitié-Salpêtrière Hospital, Paris, France,3 Université Pierre et Marie Curie-Paris 6, EA 2387, Paris, F-75013 France4

Received 23 January 2006/ Returned for modification 24 March 2006/ Accepted 25 April 2006

We analyzed 3,475 human immunodeficiency virus sequences and 241 therapeutic histories. The L74I mutation was carried by 7% of viruses. L74I was strongly associated with T215F, K70R, and V75M/S/T/A mutations and increased with the number of thymidine analog mutations. It seemed to be linked to the use of abacavir or efavirenz.

* Corresponding author. Mailing address: Pitié-Salpêtrière Hospital, Department of Virology, CERVI, 83, blvd de l'hôpital, 75013 Paris, France. Phone: 33142177401. Fax: 33142177411. E-mail: marc.wirden{at}psl.aphp.fr.

Antimicrobial Agents and Chemotherapy, July 2006, p. 2553-2556, Vol. 50, No. 7
0066-4804/06/$08.00+0     doi:10.1128/AAC.00092-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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Copyright © 2006 by the American Society for Microbiology. All rights reserved.