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Antimicrobial Agents and Chemotherapy, July 2006, p. 2557-2559, Vol. 50, No. 7
0066-4804/06/$08.00+0     doi:10.1128/AAC.00207-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Effect of Cell Culture Conditions on the Anticytomegalovirus Activity of Maribavir

Sunwen Chou,* Laura C. Van Wechel, and Gail I. Marousek

Medical and Research Services, VA Medical Center and Oregon Health & Science University, Portland, Oregon

Received 16 February 2006/ Returned for modification 10 April 2006/ Accepted 28 April 2006

The cytomegalovirus UL97 kinase inhibitor maribavir suppressed viral growth more effectively in lung fibroblasts than in skin fibroblasts, and some cellular kinase inhibitors enhanced its antiviral activity. These effects influence the phenotypic assay of drug susceptibility and suggest the possibility of therapeutically useful combinations of maribavir and cellular kinase inhibitors.

* Corresponding author. Mailing address: VA Medical Center P3ID, 3710 SW U.S. Veterans Hospital Road, Portland, OR 97239. Phone: (503) 273-5115. Fax: (503) 273-5116. E-mail: chous{at}ohsu.edu.

Antimicrobial Agents and Chemotherapy, July 2006, p. 2557-2559, Vol. 50, No. 7
0066-4804/06/$08.00+0     doi:10.1128/AAC.00207-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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