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Antimicrobial Agents and Chemotherapy, July 2006, p. 2560-2562, Vol. 50, No. 7
0066-4804/06/$08.00+0     doi:10.1128/AAC.00264-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Intrinsic Macrolide Resistance of the Mycobacterium tuberculosis Complex Is Inducible

Nadya Andini1 and Kevin A. Nash1,2*

Department of Pathology and Laboratory Medicine, Saban Research Institute of Childrens Hospital Los Angeles,1 Department of Pathology, University of Southern California, Los Angeles, California2

Received 2 March 2006/ Returned for modification 1 April 2006/ Accepted 27 April 2006

Mycobacterium tuberculosis is intrinsically resistant to macrolides, a characteristic associated with expression of the erm(37) gene. This intrinsic resistance was found to be inducible with clarithromycin and the ketolide HMR3004. Furthermore, underlying the phenotypic induction was an increase in erm(37) mRNA levels.

* Corresponding author. Mailing address: Department of Pathology and Laboratory Medicine, Saban Research Institute of Children’s Hospital Los Angeles, 4650 Sunset Blvd., Mailstop 103, Los Angeles, CA 90027. Phone: (323) 669-5670. Fax: (323) 668-7989. E-mail: kanash{at}usc.edu.

Antimicrobial Agents and Chemotherapy, July 2006, p. 2560-2562, Vol. 50, No. 7
0066-4804/06/$08.00+0     doi:10.1128/AAC.00264-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Nash, K. A., Brown-Elliott, B. A., Wallace, R. J. Jr. (2009). A Novel Gene, erm(41), Confers Inducible Macrolide Resistance to Clinical Isolates of Mycobacterium abscessus but Is Absent from Mycobacterium chelonae. Antimicrob. Agents Chemother. 53: 1367-1376 [Abstract] [Full Text]  


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