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Antimicrobial Agents and Chemotherapy, July 2006, p. 2569-2572, Vol. 50, No. 7
0066-4804/06/$08.00+0     doi:10.1128/AAC.00291-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Characterizing the Effects of Caspofungin on Candida albicans, Candida parapsilosis, and Candida glabrata Isolates by Simultaneous Time-Kill and Postantifungal-Effect Experiments

Cornelius J. Clancy,1,2* Hong Huang,2 Shaoji Cheng,2 Hartmut Derendorf,3 and M. Hong Nguyen1,2,4

North Florida/South Georgia VA Medical Center,1 Departments of Medicine,2 Molecular Genetics and Microbiology, University of Florida College of Medicine,4 Department of Pharmaceutics, University of Florida College of Pharmacy, Gainesville, Florida 326103

Received 7 March 2006/ Returned for modification 1 April 2006/ Accepted 27 April 2006

We measured time-kills and postantifungal effects (PAFEs) of caspofungin against Candida albicans, C. parapsilosis, and C. glabrata isolates. One-hour exposure to caspofungin during PAFE experiments accounted for the majority of killing during time-kill experiments. Regrowth of all isolates was inhibited for at least 24 h following drug washout.

* Corresponding author. Mailing address: University of Florida College of Medicine, Department of Medicine, Box 100277 JHMHC, 1600 SW. Archer Rd., Gainesville, FL 32610. Phone: (352) 392-4058. Fax: (352) 271-4566. E-mail: clancyn{at}medicine.ufl.edu.

Antimicrobial Agents and Chemotherapy, July 2006, p. 2569-2572, Vol. 50, No. 7
0066-4804/06/$08.00+0     doi:10.1128/AAC.00291-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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