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Antimicrobial Agents and Chemotherapy, July 2006, p. 2573-2576, Vol. 50, No. 7
0066-4804/06/$08.00+0     doi:10.1128/AAC.01633-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Naturally Occurring Extended-Spectrum Cephalosporinases in Escherichia coli

Hedi Mammeri, Laurent Poirel, Nicolas Fortineau, and Patrice Nordmann*

Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, Université Paris-Sud, 94275 Le Kremlin-Bicêtre, France

Received 22 December 2005/ Returned for modification 15 February 2006/ Accepted 27 April 2006

Genetic and functional characterization of the cephalosporinases produced by 65 clonally unrelated clinical Escherichia coli isolates revealed genetic diversity of the ampC genes and showed that Gln287, Cys287, Pro296, Leu298, and Phe350 substitutions were involved in extension of the hydrolysis spectrum to include ceftazidime and cefepime.

* Corresponding author. Mailing address: Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78 rue du Général Leclerc, 94275 Le Kremlin-Bicêtre Cedex, France. Phone: 33-1-45-21-36-32. Fax: 33-1-45-21-63-40. E-mail: nordmann.patrice{at}bct.ap-hop-paris.fr.

Antimicrobial Agents and Chemotherapy, July 2006, p. 2573-2576, Vol. 50, No. 7
0066-4804/06/$08.00+0     doi:10.1128/AAC.01633-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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