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Antimicrobial Agents and Chemotherapy, July 2006, p. 2577-2582, Vol. 50, No. 7
0066-4804/06/$08.00+0     doi:10.1128/AAC.00260-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Interactions between Glycopeptides and ß-Lactams against Isogenic Pairs of Teicoplanin-Susceptible and -Resistant Strains of Staphylococcus haemolyticus

Carla Vignaroli, Francesca Biavasco, and Pietro E. Varaldo*

Institute of Microbiology and Biomedical Sciences, Polytechnic University of Marche, 60131 Ancona, Italy

Received 2 March 2006/ Accepted 9 April 2006

Four isogenic derivatives with stably increased glycopeptide MICs (all become resistant to teicoplanin) were obtained from four glycopeptide-susceptible clinical isolates of Staphylococcus haemolyticus. All strains were extensively analyzed and compared for a number of distinctive features. In particular, the results provided insights into the puzzling issue of antistaphylococcal interactions between glycopeptides and ß-lactams, especially the paradox of double zones around ß-lactam disks and the relationships between autolysis rate and type of interaction.

* Corresponding author. Mailing address: Institute of Microbiology and Biomedical Sciences, Polytechnic University of Marche, Via Ranieri, Monte d'Ago, 60131 Ancona, Italy. Phone: 39 071 2204694. Fax: 39 071 2204693. E-mail: pe.varaldo{at}univpm.it.

Antimicrobial Agents and Chemotherapy, July 2006, p. 2577-2582, Vol. 50, No. 7
0066-4804/06/$08.00+0     doi:10.1128/AAC.00260-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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