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Interactions between Glycopeptides and ß-Lactams against Isogenic Pairs of Teicoplanin-Susceptible and -Resistant Strains of Staphylococcus haemolyticus

Institute of Microbiology and Biomedical Sciences, Polytechnic University of Marche, 60131 Ancona, Italy

Received 2 March 2006/ Accepted 9 April 2006

Four isogenic derivatives with stably increased glycopeptide MICs (all become resistant to teicoplanin) were obtained from four glycopeptide-susceptible clinical isolates of Staphylococcus haemolyticus. All strains were extensively analyzed and compared for a number of distinctive features. In particular, the results provided insights into the puzzling issue of antistaphylococcal interactions between glycopeptides and ß-lactams, especially the paradox of double zones around ß-lactam disks and the relationships between autolysis rate and type of interaction.