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Antimicrobial Agents and Chemotherapy, July 2006, p. 2583-2586, Vol. 50, No. 7
0066-4804/06/$08.00+0     doi:10.1128/AAC.01432-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Activity of Retapamulin (SB-275833), a Novel Pleuromutilin, against Selected Resistant Gram-Positive Cocci

Ronald N. Jones,1,2 Thomas R. Fritsche,1 Helio S. Sader,1 and James E. Ross1*

JMI Laboratories, North Liberty, Iowa 52317,1 Tufts University School of Medicine, Boston, Massachusetts 021112

Received 7 November 2005/ Returned for modification 25 January 2006/ Accepted 12 April 2006

Retapamulin (SB-275833), the first pleuromutilin to be developed for human topical use, was tested against a selected population of staphylococci and ß-hemolytic streptococci. The MIC90 results for retapamulin were 0.12 µg/ml for Staphylococcus aureus and ≤0.03 µg/ml for Streptococcus pyogenes; no cross-resistance was observed for organism subsets resistant to oxacillin, erythromycin, or mupirocin.

* Corresponding author. Mailing address: JMI Laboratories, Inc., 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317. Phone: (319) 665-3370. Fax: (319) 665-3371. E-mail: jim-ross{at}jmilabs.com.

Antimicrobial Agents and Chemotherapy, July 2006, p. 2583-2586, Vol. 50, No. 7
0066-4804/06/$08.00+0     doi:10.1128/AAC.01432-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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