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Antimicrobial Agents and Chemotherapy, August 2006, p. 2820-2823, Vol. 50, No. 8
0066-4804/06/$08.00+0     doi:10.1128/AAC.00324-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Evolution of Drug Resistance in Different Sublineages of Mycobacterium tuberculosis Beijing Genotype

Igor Mokrousov,1* Wei Wei Jiao,2 Gui Zhi Sun,3 Jia Wen Liu,3 Violeta Valcheva,4 Mo Li,2 Olga Narvskaya,1 and A Dong Shen2*

Laboratory of Molecular Microbiology, St. Petersburg Pasteur Institute, 197101 St. Petersburg, Russia,1 Public Central Laboratory, Beijing Pediatric Institute, Beijing Children's Hospital Affiliated to Capital University of Medical Sciences, 56 Nan Li Shi Road, Xi Cheng District, Beijing 100045, China,2 Clinical Laboratory, Beijing Chest Hospital, Wenquan Town, Haidian District, Beijing 100095, China,3 Department of Pathogenic Bacteria, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria4

Received 16 March 2006/ Returned for modification 15 May 2006/ Accepted 2 June 2006

We compared the population structure and drug resistance patterns of the Mycobacterium tuberculosis strains currently circulating in the Beijing area of China. One hundred thirteen of 123 strains belonged to the Beijing family genotypes defined by spoligotyping. The Beijing genotype strains were further subdivided into old and modern sublineages on the basis of NTF locus analysis. A stronger association with resistance to the more recently introduced antituberculosis drugs has been observed for old versus modern strains of the Beijing genotype, suggesting that its different sublineages may differ in their mechanisms of adaptation to drug selective pressure.

* Corresponding author. Mailing address for Igor Mokrousov: Laboratory of Molecular Microbiology, St. Petersburg Pasteur Institute, 14 Mira Street, 197101 St. Petersburg, Russia. Phone: 7812 2332149. Fax: 7812 2329217. E-mail: igormokrousov{at}yahoo.com. Mailing address for A Dong Shen: Public Central Laboratory, Beijing Pediatric Institute, Beijing Children's Hospital Affiliated to Capital University of Medical Sciences, 56 Nan Li Shi Road, Xi Cheng District, Beijing 100045, China. Phone: 8610 68028401. Fax: 8610 68011503. E-mail: shenad{at}sohu.com.

Antimicrobial Agents and Chemotherapy, August 2006, p. 2820-2823, Vol. 50, No. 8
0066-4804/06/$08.00+0     doi:10.1128/AAC.00324-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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