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Antimicrobial Agents and Chemotherapy, August 2006, p. 2829-2832, Vol. 50, No. 8
0066-4804/06/$08.00+0     doi:10.1128/AAC.00524-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Killing Kinetics of Caspofungin, Micafungin, and Amphotericin B against Candida guilliermondii

Emilia Cantón,1* Javier Pemán,2 Macrina Sastre,1 Mónica Romero,1 and Ana Espinel-Ingroff3

Unidad de Microbiología Experimental-Centro de Investigación,1 Servicio de Microbiología, Hospital Universitario La Fe, 46009 Valencia, Spain,2 Division of Infectious Disease, VCU Medical Center, Richmond, Virginia 23298-00493

Received 28 April 2006/ Returned for modification 13 May 2006/ Accepted 5 June 2006

Amphotericin B (AMB), micafungin, and caspofungin MICs, minimal fungicidal concentrations, and time-killing curves were determined in the presence and absence of 10% inactivated serum. AMB was the only agent with consistent killing activity (time required to achieve 99.9% of growth reduction was 2.1 to 3.2 h). The presence of serum enhanced caspofungin activity but lowered those of micafungin and AMB.

* Corresponding author. Mailing address: Unidad de Microbiología Experimental, Centro de Investigación, Hospital Universitario La Fe, Avenida Campanar 21, 46009 Valencia, Spain. Phone: 34 96 1973111. Fax: 34 96 3868718. E-mail: canton_emi{at}gva.es.

Antimicrobial Agents and Chemotherapy, August 2006, p. 2829-2832, Vol. 50, No. 8
0066-4804/06/$08.00+0     doi:10.1128/AAC.00524-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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  • Kabbara, N., Lacroix, C., Peffault de Latour, R., Socie, G., Ghannoum, M., Ribaud, P. (2008). Breakthrough C. parapsilosis and C. guilliermondii blood stream infections in allogeneic hematopoietic stem cell transplant recipients receiving long-term caspofungin therapy. haematol 93: 639-640 [Full Text]  


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